CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; DEGEE 2018 Feb 1;162:8-15. doi: 10.1016/j.colsurfb.2017.11.012. . Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Passive delivery of protein drugs through transdermal route. Commonly used in paints. Rahim et al. Diethylene Glycol is an aliphatic diol. Journal of Colloid and Interface Science. Clipboard, Search History, and several other advanced features are temporarily unavailable. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. Ethyl Diglycol is used as a flow and gloss promoter in paint industries. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. August 2017 in Formulating. Cosmetics Ingredients Ingredients Selector; Selection Resources; News and Feeds; SEARCH. Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures. The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. 2014 Oct;72:40-50. doi: 10.1016/j.fct.2014.06.028. Diethylene Glycol Monoethyl Ether is also used a solubilizer in drilling and cutting coolants. 2020 Feb;13(2):22-29. Artificial Cells, Nanomedicine, and Biotechnology. Diethylene Glycol Monoethyl Ether has low setting point and low viscocity at low temperature so it is used in manufacturing Brake Fluid. 5.0 (1) "Customer service" "Great company" Contact Supplier. Diethylene glycol monoethyl ether is asolubilising agent and an absorption enhancer used in veterinary medicine. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Would you like email updates of new search results? Learn about our remote access options. Diethylenglycolmonoethylether ist eine farblose Flüssigkeit mit süß-muffig bis fruchtigem Geruch. It is miscible in water (at 25°C) and organic solvents. See EPA’s About PDF page to learn more. Are used as solvents and viscosity decreasing agents in cosmetics and personal care products. Up to half of the applied solvent crosses the skin's barrier and becomes systemic. Buy Glycol Ether DB For $43 | Buy Diethylene Glycol Online | SDS | Shipped FedEx | Diethylene Glycol Monoethyl Ether | High Boiling Point Glycol Ether | Purified | CAS 111-90-0 | Formula C6H14O3 | 2-(2-Ethoxyethoxy)ethanol | Solvent & Coupling Agent | Glycol Ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. 2009 Jun;10(9):1515-21. doi: 10.1517/14656560903002097. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. Print Share. Please check your email for instructions on resetting your password. DRBOB@VERDIENT.BIZ Member. Enhancing oral absorption of poorly water-soluble herb ( It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. It is supplied as a urethane grade solvent. Flash point near 190°F. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. 112-34-5 You may need a PDF reader to view some of the files on this page. Expert Opin Pharmacother. Diethylene glycol monoethyl ether belongs to the family of glycol ethers. Ethyl Carbitol is used in production of printing ink and as a cleaner in offset printing. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Diethylene glycol monoethyl ether (Ethoxydiglycol) victoriayepez Member. 2009;10(4):221-7. doi: 10.2165/00128071-200910040-00002. See EPA’s About PDF page to learn more. For certain drug actives, this solvent provides for an intracutaneous depot. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. Pharmaceutical Development and Technology. US $3.50-$4.10 / Kilogram. Tagged: odor; glycol ethers; Comments. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions. To provide dermatologists a review of this solvent's safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. USA.gov. 190 Kilograms (Min. Ethoxylation is a chemical reaction in which ethylene oxide is added to a substrate. and you may need to create a new Wiley Online Library account. The substance is known to be used in oral, topical and injectable formulation s in several animal species as well as in human medicines and in cosmetics. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. Synonyms. Diethylene glycol monoethyl ether: DEGEE: 112-07-2: Ethanol, 2-butoxy-, acetate: Ethylene glycol monobutyl ether acetate: EGBEA: 112-34-5: Ethanol, 2-(2-butoxyethoxy)- Diethylene glycol monobutyl ether: DEGBE: a The CAS RN is the property of the American Chemical Society and any use or redistribution, except as required in supporting regulatory requirements and/or for reports to the … Diethyl Glycol Monoethyl Ether - CAS No. August 2017. If you do not receive an email within 10 minutes, your email address may not be registered, The effect of diethylene glycol monoethyl ether on skin penetration ability of diclofenac acid nanosuspensions. Conclusions: Eigenschaften. The microemulsion prepared … Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. [125] compared two columns (SPB-35 column vs. ATTM AQUAWAX column) for the separation of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food. 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